Project C2

The influence of stroma-metastasis interaction on tumor evolution

Andreas Beyer, CECAD and U Cologne | web | email
Axel Hillmer, U Cologne | web | email

In this project, we will characterize adaptive processes of a tumor enabling its establishment as a metastasis and predict the seeding probability as a function of the cell’s mutations and the tumor environment. By single-nucleus RNA-sequencing, we will characterize the transcriptomic state of cancer cells, immune cells, and stromal cells of both the primary tumor and the metastasis. Using systems-scale computational modelling, we will infer adaptive responses of cancer cells to their environment and adaptive responses of stromal cells to the tumor.

Predictability in Evolution

Collaborative Research Center 1310