Project C1

How cell death shapes tumor evolution during carcinogenesis

Johannes Berg, U Cologne | web | email
Silvia von Karstedt, CECAD | web | email

We look at the role of cell death in cancer evolution. How do population of cancer cells evolve when different cell death mechanisms are deactivated? How do mutations accumulate under different rates of cell death and how do they affect the fitness of the final populations? Is there a reproducible order in which cell death mechanisms are deactivated? To address these questions, we will combine cell-culture and in-vivo mouse experiments with mathematical modelling to ultimately predict trajectories of cell-death pathway deactivation.

Predictability in Evolution

Collaborative Research Center 1310