Project B6

Evolutionary models for spatially structured tumors

Johannes Berg, U Cologne | web | email

The project builds spatially structured population genetics models for tumor evolution, including cell migration and clonal interference, and develops methods to infer evolutionary parameters from tumor sequence data. These data and models will be used to predict the likelihood of resistance mutations in solid tumors under therapy.

Predictability in Evolution

Collaborative Research Center 1310


Stochastic clonal dynamics and genetic turnover in exponentially growing populations

Angaji A., Velling C. and Berg J., J. Stat. Mech. 103502, 26. October 2021,

Network inference in the nonequilibrium steady state

Dettmer S., Nguyen H. C., and Berg J., Phys. Rev. E 94 (5) 052116, 10. November 2016,

Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors

Ortiz-Cuaran S., […], Berg J., […], Thomas R., Clinical Cancer Research 1915.2015, 1. June 2016,