Project B4

Co-evolution of gut microbiota and immune cells during ageing in killifish

Melike Dönertas, Leibniz Institute on Aging (FLI) | web | email
Dario Riccardo Valenzano, Leibniz Institute on Aging (FLI) | web | email

We experimentally track the evolution of immune repertoires and microbes in killifish, a model organism of vertebrate ageing. This project develops a predictive approach for the co-evolutionary dynamics of fish B-cell diversity, microbial composition and genetic changes in microbes during the entire host lifespan. Our predictions will include effects of these dynamics on individual ageing.

Predictability in Evolution

Collaborative Research Center 1310


Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish

Bradshaw W.J., Poeschla M., Placzek A., Kean S., Valenzano D.R., eLife, 7. February 2022,

Intra-species differences in population size shape life history and genome evolution

Willemsen D., Cui R., Reichard M., Valenzano D.R., eLife 2020;9:e55794, 1. September 2020,

Microbiota–host interactions shape ageing dynamics

Popkes M., Valenzano D.R., Phil. Trans. R. Soc. B 375, 20190596, 10. August 2020,

Nothobranchius furzeri (African Turquoise Killifish)

Cui R., Willemsen D., Valenzano D.R., Trends In Genetics, 1. July 2020,

Extreme genomic volatility characterizes the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes

Bradshaw W.J., Valenzano D.R., Proc. R. Soc. B.28720200489, 13. May 2020,

Relaxed Selection Limits Lifespan by Increasing Mutation Load

Cui R., Medeiros T., Willemsen D., Iasi L.N.M, Collier G.R., Graef M., Reichard M., Valenzano D.R., Cell 11;178(2):385-399.e20, 27. June 2019, 10.1016/j.cell.2019.06.004

The short-lived African turquoise killifish (Nothobranchius furzeri): a new model system for research on ageing.                                                     "Conn's Handbook of Models of Human Aging

Muck J., Kean S., Valenzano D.R.,Academic Press, 2. May 2018, ISBN: 9780128113530

A Protocol for Laboratory Housing of Turquoise Killifish (Nothobranchius furzeri)

Dodzian J., Kean S., Seidel J., Valenzano D.R., J. Vis. Exp. (134) e57073, 11. April 2018,