Project A6

Evolutionary diversification of E. coli in the mouse gut

Isabel Gordo, Instituto Gulbenkian de Ciência | web | email

This project studies gut evolution of E. coli strains in health and disease. We will characterize genetic and phenotypic diversification of highly evolvable strains and quantify emerging evolutionary trade-offs using new mathematical models. We will study the co-evolution between colibactin positive and negative strains and gut epithelia cells during cancer development.

Predictability in Evolution

Collaborative Research Center 1310


Two modes of evolution shape bacterial strain diversity in the mammalian gut for thousands of generations

Frazão N., Konrad A., Amicone M., Seixas E., Güleresi D., Lässig M. and Gordo I., Nature Communications, 23. September 2022,

Mutation accumulation and horizontal gene transfer in Escherichia coli colonizing the gut of old mice

Barreto H.C., Frazão N., Sousa A., Konrad A., & Gordo I., Communicative & Integrative Biology, 13:1, 89-96, 24. June 2020,

Low mutational load and high mutation rate variation in gut commensal bacteria

Ramiro R.S., Durão P., Bank C., Gordo I., PLoS Biol 18 (3): e3000617. , 10. May 2020,

Horizontal gene transfer overrides mutation in Escherichia coli colonizing the mammalian gut

Frazão N., Sousa A., Lässig M., and Gordo I., PNAS:201906958, 20. August 2019,

A Mutational Hotspot and Strong Selection Contribute to the Order of Mutations Selected for during Escherichia coli Adaptation to the Gut

Lourenço M., Ramiro R.S., Güleresi D., Barroso-Batista J., Xavier K.B., Gordo I., Sousa A., PLoS Genetics 12(11):e1006420, 3. November 2016,

Macrophage adaptation leads to parallel evolution of genetically diverse Escherichia coli small‐colony variants with increased fitness in vivo and antibiotic collateral sensitivity

Ramiro R.S., Costa H., Gordo I., Evolutionary Applications 9(8):994-1004, 27. May 2016,