Project A5

Fitness effects of cross-species gene transfer in bacteria

Berenike Maier, U Cologne | web | email

Project A5 focuses on genome-wide evolution by lateral gene transfer across related Bacillus species. Massively parallel experiments map fitness effects governing the dynamics of gene transfer, including adaptive benefits and fitness barriers generated by functional mismatches between genes from different species in a single organism.

Predictability in Evolution

Collaborative Research Center 1310


Genome-wide transformation reveals extensive exchange across closely related Bacillus species

Förster M., Rathman I., Yüksel M., Power J., Maier B., Nucleic Acids Reasearch, 16. November 2023,

Collective polarization dynamics in bacterial colonies signify the occurrence of distinct subpopulations

Hennes M., Bender N., Cronenberg T., Welker A., Maier B., PLOS Biol, 18. January 2023,

Distribution of fitness effects of cross-species transformation reveals potential for fast adaptive evolution

Rathmann I., Förster M., Yüksel M., Horst L., Petrungaro G., Bollenbach T., Maier B., ISME J, 12. October 2022,

Adaptive evolution of hybrid bacteria by horizontal gene transfer

Power J.J., Pinheiro F., Pompei S., Kovacova V., Yüksel M., Rathmann I., Förster M., Lässig M., Maier B., PNAS 11, 118 (10), 9. March 2021,

Bacterial Translocation Ratchets: Shared Physical Principles with Different Molecular Implementations

Hepp C., Maier B., BioEssays, 39: 1700099, 12. September 2017,

Kinetics of DNA uptake during transformation provide evidence for a translocation ratchet mechanism

Hepp C., Maier B., PNAS 113(44): 12467, 17. October 2016,

Fitness Trade-Offs in Competence Differentiation of Bacillus subtilis

Yüksel M., Power J.J., Ribbe J., Volkmann T., Maier B., Front. Microbiol. 7: 888, 7. June 2016,