Evolutionary models for spatially structured tumors
The project builds spatially structured population genetics models for tumor evolution, including cell migration and clonal interference, and develops methods to infer evolutionary parameters from tumor sequence data. These data and models will be used to predict the likelihood of resistance mutations in solid tumors under therapy.
Predictability in Evolution
Collaborative Research Center 1310
Dettmer S., Nguyen H. C., and Berg J., Phys. Rev. E 94 (5) 052116, 10. November 2016, https://doi.org/10.1103/PhysRevE.94.052116
Ortiz-Cuaran S., […], Berg J., […], Thomas R., Clinical Cancer Research 1915.2015, 1. June 2016, https://doi.org/10.1158/1078-0432.CCR-15-1915