Project B4
Co-evolution of gut microbiota and immune cells during ageing in killifish
Melike Dönertas, Leibniz Institute on Aging (FLI) | web | email
Dario Riccardo Valenzano, Leibniz Institute on Aging (FLI) | web | email
We experimentally track the evolution of immune repertoires and microbes in killifish, a model organism of vertebrate ageing. This project develops a predictive approach for the co-evolutionary dynamics of fish B-cell diversity, microbial composition and genetic changes in microbes during the entire host lifespan. Our predictions will include effects of these dynamics on individual ageing.
Predictability in Evolution
Collaborative Research Center 1310
Publications
Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish
Bradshaw W.J., Poeschla M., Placzek A., Kean S., Valenzano D.R., eLife, 7. February 2022, https://doi.org/10.7554/eLife.65117
Intra-species differences in population size shape life history and genome evolution
Willemsen D., Cui R., Reichard M., Valenzano D.R., eLife 2020;9:e55794, 1. September 2020, https://doi.org/10.7554/eLife.55794
Microbiota–host interactions shape ageing dynamics
Popkes M., Valenzano D.R., Phil. Trans. R. Soc. B 375, 20190596, 10. August 2020, https://doi.org/10.1098/rstb.2019.0596
Nothobranchius furzeri (African Turquoise Killifish)
Cui R., Willemsen D., Valenzano D.R., Trends In Genetics, 1. July 2020, https://doi.org/10.1016/j.tig.2020.01.012
Bradshaw W.J., Valenzano D.R., Proc. R. Soc. B.28720200489, 13. May 2020, https://doi.org/10.1098/rspb.2020.0489
Relaxed Selection Limits Lifespan by Increasing Mutation Load
Cui R., Medeiros T., Willemsen D., Iasi L.N.M, Collier G.R., Graef M., Reichard M., Valenzano D.R., Cell 11;178(2):385-399.e20, 27. June 2019, 10.1016/j.cell.2019.06.004
Muck J., Kean S., Valenzano D.R.,Academic Press, 2. May 2018, ISBN: 9780128113530
A Protocol for Laboratory Housing of Turquoise Killifish (Nothobranchius furzeri)
Dodzian J., Kean S., Seidel J., Valenzano D.R., J. Vis. Exp. (134) e57073, 11. April 2018, https://doi.org/10.3791/57073