Co-evolution of gut microbiota and immune cells during ageing in killifish
We experimentally track the evolution of immune repertoires and microbes in killifish, a model organism of vertebrate ageing. This project develops a predictive approach for the co-evolutionary dynamics of fish B-cell diversity, microbial composition and genetic changes in microbes during the entire host lifespan. Our predictions will include effects of these dynamics on individual ageing.
Predictability in Evolution
Collaborative Research Center 1310
Muck J., Kean S., Valenzano D.R.,Academic Press, 2. May 2018, ISBN: 9780128113530
Dodzian J., Kean S., Seidel J., Valenzano D.R., J. Vis. Exp. (134) e57073, 11. April 2018, https://doi.org/10.3791/57073