Project B3

Adaptive immune control of evolving pathogens

Armita Nourmohammad, MPI for Dyn. and Self-Organ. | web | email

This project will model and infer selection on B cell immune repertoires, which is a key building block of evolutionary models for broadly neutralizing antibodies. Based on these models, we will develop a stochastic control theory for HIV antibodies that predicts optimal protocols to elicit broad neutralization characteristics.

Predictability in Evolution

Collaborative Research Center 1310


Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape

Wu N. C., Otwinowski J., Thompson A. J., Nycholat C. M. Nourmohammad A and Wilson I. A., Nat Commun 11, 1233, 6. March 2020,

The size of the immune repertoire of bacteria

Bradde S., Nourmohammad A., Goyal S., and Balasubramanian V., PNAS:201903666, 18. February 2020,

Fierce Selection and Interference in B-Cell Repertoire Response to Chronic HIV-1

Nourmohammad A., Otwinowski J., Łuksza M., Mora T., M. Walczak A., Molecular Biology and Evolution, msz143, 18. June 2019,

Adaptive Evolution of Gene Expression in Drosophila

Nourmohammad A., Rambeau J., Held T., Kovacova V., Berg J., Lässig M., Cell Reports Volume 20 Issue 6: 1385 - 1395, 13. July 2017,          

Host-Pathogen Coevolution and the Emergence of Broadly Neutralizing Antibodies in Chronic Infections

Nourmohammad A., Otwinowski J., Plotkin J.B., PLoS Genetics 12: e1006171, 21. July 2016,