Adaptive immune control of evolving pathogens
This project will model and infer selection on B cell immune repertoires, which is a key building block of evolutionary models for broadly neutralizing antibodies. Based on these models, we will develop a stochastic control theory for HIV antibodies that predicts optimal protocols to elicit broad neutralization characteristics.
Predictability in Evolution
Collaborative Research Center 1310
Nourmohammad A., Otwinowski J., Łuksza M., Mora T., M. Walczak A., Molecular Biology and Evolution, msz143, 18. June 2019, https://doi.org/10.1093/molbev/msz143
Nourmohammad A., Rambeau J., Held T., Kovacova V., Berg J., Lässig M., Cell Reports Volume 20 Issue 6: 1385 - 1395, 13. July 2017, https://doi.org/10.1016/j.celrep.2017.07.033
Nourmohammad A., Otwinowski J., Plotkin J.B., PLoS Genetics 12: e1006171, 21. July 2016, https://doi.org/10.1371/journal.pgen.1006171