Project B3

Adaptive immune control of evolving pathogens

Armita Nourmohammad, MPI for Dyn. and Self-Organ. | web | email

This project will model and infer selection on B cell immune repertoires, which is a key building block of evolutionary models for broadly neutralizing antibodies. Based on these models, we will develop a stochastic control theory for HIV antibodies that predicts optimal protocols to elicit broad neutralization characteristics.

Predictability in Evolution

Collaborative Research Center 1310

Publications

Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape

Wu N. C., Otwinowski J., Thompson A. J., Nycholat C. M. Nourmohammad A and Wilson I. A., Nat Commun 11, 1233, 6. March 2020, https://doi.org/10.1038/s41467-020-15102-5

The size of the immune repertoire of bacteria

Bradde S., Nourmohammad A., Goyal S., and Balasubramanian V., PNAS:201903666, 18. February 2020, https://doi.org/10.1073/pnas.1903666117

Fierce Selection and Interference in B-Cell Repertoire Response to Chronic HIV-1

Nourmohammad A., Otwinowski J., Łuksza M., Mora T., M. Walczak A., Molecular Biology and Evolution, msz143, 18. June 2019, https://doi.org/10.1093/molbev/msz143

Adaptive Evolution of Gene Expression in Drosophila

Nourmohammad A., Rambeau J., Held T., Kovacova V., Berg J., Lässig M., Cell Reports Volume 20 Issue 6: 1385 - 1395, 13. July 2017,                    https://doi.org/10.1016/j.celrep.2017.07.033

Host-Pathogen Coevolution and the Emergence of Broadly Neutralizing Antibodies in Chronic Infections

Nourmohammad A., Otwinowski J., Plotkin J.B., PLoS Genetics 12: e1006171, 21. July 2016, https://doi.org/10.1371/journal.pgen.1006171

imprint