Project B2

Predicting viral-immune co-evolution

Michael Lässig, U Cologne | web | email

We focus on phenotypic fitness models for viral pathogens based on antigen-antibody interactions. These models predict near-future mutations of the influenza virus, as well as vaccination efficacy and feedbacks of vaccination on viral evolution. They will also be applied to HIV escape evolution from neutralizing antibodies, in collaboration with project B1.

Predictability in Evolution

Collaborative Research Center 1310


Gene expression variability across cells and species shapes innate immunity

Hagai T., Chen X., Miragaia R. J., Rostom R., Gomes T., Kunowska N., Henriksson J., Park J.-E., Proserpio V., Donati G., Bossini-Castillo L., Vieira Braga F. A., Naamati G., Fletcher J., Stephenson E., Vegh P., Trynka G., Kondova I., Dennis M., Haniffa M., Nourmohammad A., Lässig M., Teichmann S. A., Nature 563: 197 - 202, 24. October 2018,

Predicting evolution

Lässig M., Mustonen V., Walczak A., Nature Ecol. Evol. 1:0077, 21. February 2017,

A predictive fitness model for influenza

Luksza M., Lässig M., Nature 507:57-61, 26. February 2014,