Project B1

Against all odds: The evolution of HIV-1-directed broadly neutralizing Antibodies

Florian Klein, U Cologne | web | email

This project performs advanced sequencing of human B cell repertoires in HIV patients and healthy individuals. In collaboration with projects B3 and B5, these data are used to predict the likelihood to evolve broadly neutralizing antibodies targeting the HIV virus. This likelihood will be compared with antibody effects on HIV populations.

Predictability in Evolution

Collaborative Research Center 1310


Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

Caskey M., Schoofs T., Gruell H., Settler A., Karagounis T., …, Klein F., Nat Med 23, 185-191, 16. January 2017,

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1

Schoofs T., Klein F., Braunschweig M., Kreider E.F., Feldmann A. et al., Science 352: 997-1001, 20. May 2016,