Project A3

A predictive fitness model for cross-species evolution

Michael Lässig, U Cologne | web | email

We build predictive fitness models for evolutionary processes involving two or more species. In collaboration with project A5, we will predict the genome-wide adaptive dynamics of gene transfer between related bacterial species and predict fitness barriers for these dynamics. Together with project A6, we will study niche-specific adaptation in the context of a complex ecosystem.

Predictability in Evolution

Collaborative Research Center 1310


Horizontal gene transfer overrides mutation in Escherichia coli colonizing the mammalian gut

Frazão N., Sousa A., Lässig M., and Gordo I., PNAS:201906958, 20. August 2019,

Survival of the simplest in microbial evolution

Held T., Klemmer D., Lässig M., Nature Communications 10: 2472, 6. June 2019,

Adaptive Evolution of Gene Expression in Drosophila

Nourmohammad A., Rambeau J., Held T., Kovacova V., Berg J., Lässig M., Cell Reports Volume 20 Issue 6: 1385 - 1395, 8. August 2017,        

Predicting evolution

Lässig M., Mustonen V., Walczak A., Nature Ecol. Evol. 1:0077, 21. February 2017,