Project A2

Predicting evolutionary pathways to β-lactam resistance

Joachim Krug, U Cologne | web | email

Arjan de Visser, Wageningen University | web | email

This project has a multi-level research agenda on drug resistance evolution. By a combination of theoretical modeling and laboratory evolution experiments, we aim at making concrete predictions about the evolution of resistance to β-lactam antibiotics. We focus on the relationship between genotype, phenotype, and fitness, including social interactions influencing resistance evolution.

Predictability in Evolution

Collaborative Research Center 1310

Publications

Rare beneficial mutations cannot halt Muller's ratchet in spatial populations

Park S.-C., Klatt P., Krug J., EPL 123: 48001, 3. September 2018, http://stacks.iop.org/0295-5075/123/i=4/a=48001

The utility of fitness landscapes and big data for predicting evolution

de Visser, J. A. G. M., Santiago F. E., Fragata I., Matuszewski S., Heredity 121: 401–405, 20. August 2018, https://doi.org/10.1038/s41437-018-0128-4

Ecology dictates evolution? About the importance of genetic and ecological constraints in adaptation

de Vos M. G. J., Schoustra S. E., de Visser J. A. G. M., EPL 122: 58002, 17. July 2018, http://stacks.iop.org/0295-5075/122/i=5/a=58002

Unraveling the causes of adaptive benefits of synonymous mutations in TEM-1 β-lactamase

Zwart M. P., Schenk M. F., Hwang S., Koopmanschap B., de Lange N., van de Pol L., Nga T. T. T., Szendro I. G., Krug J., de Visser J. A. G. M., Heredity 121: 406–421, 2. July 2018, https://doi.org/10.1038/s41437-018-0104-z

Universality Classes of Interaction Structures for NK Fitness Landscapes

Hwang S., Schmiegelt B., Ferretti L., Krug J., J Stat Phys 172: 226, 13. February 2018, https://doi.org/10.1007/s10955-018-1979-z

Local Fitness Landscapes Predict Yeast Evolutionary Dynamics in Directionally Changing Environments

Gorter F. A., Aarts M. G. M, Zwaan B. J., de Visser J. A. G. M., Genetics 208: 307-322, 1. January 2018, https://doi.org/10.1534/genetics.117.300519

Adaptive benefits from small mutation supplies in an antibiotic resistance enzyme

Salverda M. L. M., Koomen J., Koopmanschap B., Zwart M. P., de Visser J. A. G. M., Proc. Natl. Acad. Sci. USA 114: 12773-12778, 13. November 2017, https://doi.org/10.1073/pnas.1712999114

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